Mitsunobu Reaction
The Mitsunobu reaction performs a stereospecific conversion
of an alcohol to a primary amine with inversion of configuration.
The alcohol is treated with triphenylphosphane, diethyl azodicarboxylate
(DEAD) and, usually, phthalimide, followed by hydrazinolysis.
References
[1] Mitsunobu, O.; Wada, M.; Sano, T. J. Am. Chem. Soc. 1972,
94, 679.
[2] Hughes, D. L. Org. Reac. 1992, 42, 335-656.
(Review: "The Mitsunobu Reaction")
Burkhard Kirste, 1994/12/16