FORMER RESEARCH GROUP OF PROF. E. RIEDEL

Thielallee 63
D-14195 Berlin

Room:
Secretary's Office: Room

phone +49-30-838-52938
fax     +49-30-838-52936

Prof. Riedel has retired

FURTHER INFORMATION

• Fachbereichs-Broschüre (Edition 1996) (mostly German !)

KEYWORDS

ABSTRACT

Only cells of the monocyte/macrophage lineage express scavenger receptors, which internalize derivatized lipoproteins. Our studies deal with lipoproteins (LDL) as cell-specific transporters of drugs against macrophage specific infections (HIV) or macrophage specific functions (TNFa, Il-1). We could show inhibition of HIV-reverse transcriptase in human HIV-infected macrophages with covalently to LDL coupled azidothymidine or fluorothymidine. Possibly antisense oligonucleotides can be internalized similarly.

In hemodialysis patients malnutrition correlates with morbidity. We have developed fluorescence HPLC methods to study amino acid and keto acid metabolism. We could show improvement of amino acid metabolism in anemic hemodialysis patients during therapy with recombinant human erythropoietin. Furthermore, diminished essential amino acids (histidine or valine) or semiessential arginine could be enhanced in hemodialysis patients by supplementation with ketoglutarate. Amino acid and keto acid metabolism was studied in a hybrid liver support bioreactor and in patients before and after transplantation of liver or kidney.